منابع مشابه
Role of TNF-α in vascular dysfunction
Healthy vascular function is primarily regulated by several factors including EDRF (endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) and EDHF (endothelium-dependent hyperpolarizing factor). Vascular dysfunction or injury induced by aging, smoking, inflammation, trauma, hyperlipidaemia and hyperglycaemia are among a myriad of risk factors that may contribut...
متن کاملTNF-α and Beyond: Rapid Mitochondrial Dysfunction Mediates TNF-α-Induced Neurotoxicity
This short communication describes our research which demonstrates that TNF-α causes a rapid decline in mitochondrial function, leading to neuronal cell death. As such, this neurotoxic proinflammatory cytokine may play a role in brain damage from stroke and neurodegeneration in chronic conditions such as Alzheimer's disease (AD) and Parkinson's disease. We have extended this initial observation...
متن کاملTnf-α Neutralization Ameliorates Obstruction-induced Renal Fibrosis and Dysfunction
Upper urinary tract obstruction results in tubulointerstitial fibrosis and a progressive decline in renal function. Although several inflammatory mediators have been implicated in the pathophysiology of renal obstruction, the contribution of tumor necrosis factor-α (TNF-α) to obstruction-induced fibrosis and renal dysfunction has not been thoroughly evaluated. To study this, male Sprague-Dawley...
متن کاملComparison of an XTT - Based TNF - α Bioassay with a TNF - α ELISA
1.Bartelt, D.C., S. Fidel, L.H. Farber, D.J. Wolff and R.L. Hammell. 1988. Calmodulin-dependent multifunctional protein kinase in A. nidulans. Proc. Natl. Acad. Sci. USA 85:3279-3283. 2.Bergen, L.G., A. Upshall and N.R. Morris. 1984. S-phase, G2, and nuclear division mutants of Aspergillus nidulans. J. Bacteriol. 159:114-119. 3.Dayton, J.S., M. Sumi, N.N. Namthakumar and A.R. Means. 1997. Expre...
متن کاملTargeting TNF-α with a tetravalent mini-antibody TNF-TeAb
Mengyuan LIU*†, Xiangbin WANG†, Changcheng YIN†, Zhong ZHANG†, Qing LIN†, Yongsu ZHEN§ and Hualiang HUANG†‡1 *Faculty of Life Science, Hubei University, 430062 Wuhan, People’s Republic of China, †Beijing ABT Genetic Engineering Technology Co. Ltd., 102206 Beijing, People’s Republic of China, §The Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical S...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2007
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858407305725